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DxNow has designed and developed fertility products to deliver the best outcome for ICSI, IUI and IVF through the use of sperm separation and preparation to aid in selection of the healthiest motile sperm possible. Update14, Worldwide, in excess ofcases involve sexual assault4.
Every seconds, another American is sexually assaulted. South Africa records the highest rates of rape in the world. DxNow, in collaboration with The Demirci Bio-Acoustic MEMS in Medicine Labs BAMM at Stanford Medicine, has developed microfluidic-based platforms for the capture and sorting of a diverse type of cells and pathogens by utilizing highly specific recognition elements including antibodies and carbohydrates.
These platform technologies have the potential of being deployed for the detection, capture and quantitation of multiple cell types from unprocessed samples. We have now applied these state-of-the-art technologies to selectively capture sperm from complex bodily fluids, a step which is crucial in forensic DNA analysis of sexual assault samples.
DxNow technology will provide a catalyst in helping to reduce DNA forensic backgrounds in cases involving sexual assault evidence. Methods for rapid and efficient processing of sexual assault evidence will accelerate forensic investigation and reduce casework backlogs. Building on our expertise in cell sorting tools incorporating shadow imaging for detection and characterization of cells, we are developing medical diagnostic devices leveraging these technologies, along with microfluidic integrated biosensors, to capture and quantify cells from unprocessed whole blood or other body fluids.
This healthcare platform technology addresses significant underserved clinical needs in the home and primary care settings for innovative, inexpensive, accurate and easy-to-use point-of-care diagnostics products.
Our technology platform is revolutionary. The inexpensive POC monitoring tools that we can deliver to the home or primary setting have not been available to date. Our products will decrease healthcare costs and have significant clinical and socio-economic benefits.
This platform will deliver accurate, rapid and inexpensive test results, minimizing unnecessary and costly ER visits and hospitalizations. Specifically, our solutions consist of i a disposable single use microfluidic cartridge to capture WBCs and neutrophils and ii a portable, easy-to-use lens-free shadow imaging system to rapidly quantify captured cell counts.
The easy-to-collect measurements and regular monitoring capabilities will provide much needed, timely treatment of patients before their conditions become acute. Our lead product focuses on significant underserved medical needs in end-stage renal disease; specifically, addressing critical clinical barriers to more widespread use of peritoneal dialysis.
Peritoneal dialysis is a preferred treatment modality that can be performed in the home setting, but is often not utilized due to the risk of peritonitis. By leveraging our technologies, we are delivering an inexpensive, disposable diagnostic that can be used in the home setting by patients to easily capture and analyze neutrophils from their dialysate to detect early indicators of peritoneal infection.
Early detection of infections at their onset will enable clinicians to start early treatment, providing significant clinical benefits: Detecting infection at the onset and preventing the infection from developing to the chronic phase Monitoring and managing peritoneal dialysis therapy more easily within the home care environment Minimizing repeat infections, which can lead to peritoneal membrane degradation and forcing patients to switch to the more expensive and less convenient hemodialysis treatment.
Beyond monitoring for peritoneal infection, this proposed platform has broad potential application in monitoring patients receiving chemotherapy and transplants, where the need for a rapid and complete blood count is applicable, as well as detecting catheter infections rapidly in many other clinical procedures.
We combine novel, portable bio-imaging systems with microfluidic-based consumables for proprietary life sciences applications that: Deliver improvements in assisted reproductive technology ART in humans and animals Facilitate faster identification of individuals for prosecution within the criminal justice system Enable advances in life science research and applied markets Provide faster, more cost-effective diagnostic solutions for chronically ill patients and their caregivers Our products are based on exclusively-licensed technologies developed in the Demirci BAMM Labs that: To address the problem, we are commercializing two products in the USA market: Furthermore, current procedures requiring centrifugation cause irreversible damage to the sperm due to DNA fragmentation and the generation of reactive oxygen species ROS.
These devices will be the first of their kind in the U. Our fertility devices eliminate the need for time-consuming sample preparation and sperm damaging centrifugation. The result is a simple and fast method, enabling the embryologist to consistently select sperm with higher motility, better morphology, less damaging ROS generation and lower DNA fragmentation.
Both devices separate sperm based on motility. The primary difference between the devices is the processing volume. More than one micro-channel is available to accommodate multiple separations. Each channel has an inlet port for applying the semen sample and an outlet port for collecting the motile sperm.
The ports are connected by a fluid-filled micro-channel in which the separating occurs.
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Untreated semen is added through the inlet port. After a period of time, the separated sperm are collected from the outlet port. The sample chamber is separated from the upper collection chamber by a microporous filter. After a period of time, the separated sperm are collected from the upper chamber through the outlet port.
In parallel to our activities in the human market, we are working with key opinion leaders KOLs in the veterinary market to validate the utility and function of these products for ART applications in animals.Starting A Chicken Farm For Layers, Broiler And Cockerels.
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